We will get her in about 3 weeks. . I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. This organic powder is great for a variety of uses. Tap to zoom. How to use Simparica Trio. (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. My Vet told me Trifexis was safe to give them. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Any thoughts? I had never heard of Dimmitrol before, but I did some research after reading your comment. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) My two cats were father and son so probably carried the same gene. Thank you very much! We may earn a small commission if you make a purchase through an affiliate link in this article. Thank you, and hello to Nola and Otis! I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. I have a new Collie-mix with bi-coloured coat. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. Any suggestions? If your dogs arent reacting to it, why are you switching? You can even scatter some on your dogs bed. Select in Checkout User warnings Wash hands after handling the product. I would appreciate your comments on Advocate. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. Sugar is a great name for a Collie as they really are such sweethearts. Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. Or is it when given together? I really do not know what to do and get no real input from my Vet. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. Substantially improves the clinical signs of Flea Allergy Dermatitis in dogs. ? Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. Excellent research and well written article! She was obviously in discomfort. . He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! The neurological problems tied to Simparica scare the shit out . Hes just a puppy himself and was already started on Interceptor and Credelio. Is Simparica safe for MDR1 dogs? 1x 10mg tablet for 5.6 to 11 pounds. Due to this fact, Pet Place warns: Simparica is administered once a month as a flavored chewable. for, I think its brown ticks. Please let me know how the Wondercide works for you! Our cat does not socialize with the Collies. I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. Hi Debbie! ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. Very recently, significantly increased brain penetration of fluralaner was demonstrated in an mdr1 mutant mouse model, indicating that MDR1-mediated drug efflux normally prevents fluralaner entry into the brain [ 21 ]. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. I am so excited. Another safe heartworm medication is the daily dimmitrol. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! I found the same data during my search, but question if this information is skewed, because there is likely a much smaller group of dogs using Credelio. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. He had been taking the it for about 2-3 months. Great summary! From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! GestorVet es el futuro de la gestin veterinaria. Are you also on Instagram, by chance? However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. Simparica Trio 11.1-22 lbs. I gave a mini aussie and a minnie aussie/border collie mix. I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. I have a one year old Aussie mix. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. It covers fleas, ticks, and heart worms. Congratulations on the new kitten. And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. Simparica Trio treats and protects against harmful parasites. $153.89. My question is about Capstar. It has the same active ingredients as Seresto (plus one), so a bit stronger. Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. So tick protection is also a must for us. I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. 1,9 And the fact is, dogs love both chews. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. Key Features of Simparica Trio. To help with this, the product can be applied in more than one line between the neck and shoulder blades. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. In summary, use with caution. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? THREE OF THE 8 FEMALES WENT INTO ESTRUS. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. First, I want to thank you for the time and effort that went into writing this article. Thousands of dogs have experienced serious adverse reactions after taking . Katie P. 11 days ago. Thank you for fostering! (357 reviews) Simparica. Is this true? If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. Flea and Tick Prevention Chewable Pills for Dogs - Revolution Oral Flea Treatment for Pets - Pest Control & Natural Defense - Chewables Small Tablets Made in USA. IMPORTANT SAFETY INFORMATION: NexGard is for use in . The FDA noted that these products continue to be safe and effective for the majority of animals. For the majority of dogs, Advecta is probably fine! Im trying to find out if this is safe for her. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. Best of luck with your new girl! Effective against ticks that may carry debilitating diseases like ehrlichiosis, anaplasmosis, and rickettsiosis 2. -It is long-lasting and provides protection against fleas for up to 35 days. Thats what Im doing for my most recent Collie. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. Also what can be used for giardia? Doses used for heartworm prevention are safe to use in these breeds of dogs. Thank you for the useful information which is a little easier (clearer) to understand than most. 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