Potentially affected entities may include, but are not limited to those engaged in the following activities: This listing is not intended to be exhaustive, but rather to provide a guide for readers regarding entities likely to be affected by this action. Application of Palisade plus Tilt reduced lodging over Palisade alone at Chickasha. Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. headings within the legal text of Federal Register documents. Personal protection: P2 filter respirator for harmful particles. If you are worried about bronzing, tank mix a product that contains manganese rather than iron. Wheat lodging is not generally a widespread problem in Oklahoma, but it does occur. The Public Inspection page may also Further information regarding EPA drinking water models used in pesticide exposure assessment can be found at http://www.epa.gov/oppefed1/models/water/index.htm. All rights reserved. Trinexapac-ethyl (Ref: CGA 163935) (Also known as: trinexapac; cimectacarb-ethyl; cimectacarb) The following alerts are based on the data in the tables below. Section 408(b)(2)(D)(v) of FFDCA requires that, when considering whether to establish, modify, or revoke a tolerance, the Agency consider available information concerning the cumulative effects of a particular pesticide's residues and other substances that have a common mechanism of toxicity. EPA has not found trinexapac-ethyl to share a common mechanism of toxicity with any other substances, and trinexapac-ethyl does not appear to produce a toxic metabolite produced by other substances. About the Federal Register In the event of a Toxic or Transport Emergency in the UK please telephone 01484538444 at any time. Rolston, C.J. Two comments were received in response to the Notice of Filing. Because this action has been exempted from review under Executive Order 12866, this action is not subject to Executive Order 13211, entitled Actions Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use (66 FR 28355, May 22, 2001) or Executive Order 13045, entitled Protection of Children from Environmental Health Risks and Safety Risks (62 FR 19885, April 23, 1997), nor is it considered a regulatory action under Executive Order 13771, entitled Reducing Regulations and Controlling Regulatory Costs (82 FR 9339, February 3, 2017). Bell. Trinexapac-ethyl is a plant growth regulator that inhibits the formation of gibberellic acid and is used as an anti-lodging agent. However, to the best of our knowledge, TE has not been used to study the requirement of GAs in onset of germination. Application of Palisade plus Tilt reduced lodging over Palisade alone at Chickasha. You must file your objection or request a hearing on this regulation in accordance with the instructions provided in 40 CFR part 178. In adult animals (rats, rabbits, mice, dogs), no systemic adverse effects are seen below the limit dose following subchronic or chronic oral exposure with the exception of dogs. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. As those sections continue to reflect the Agency's current position on those topics, those sections are incorporated here by reference. Trinexapac-ethyl (TE), a GA synthesis inhibitor, is frequently used as a plant growth regulator in crop production. Palisade is a giberellic acid inhibitor and works primarily by reducing plant height. This feature is not available for this document. Trinexapac-ethyl; tolerances for residues. Trinexapac-ethyl is classified as "Not likely to be carcinogenic to humans." The combined chronic toxicity/carcinogenicity study in the rat did not demonstrate an increase in any tumor type that would be relevant to humans. Relevant information about this document from Regulations.gov provides additional context. Based on the lack of evidence of carcinogenicity in two adequate rodent carcinogenicity studies, trinexapac-ethyl is not expected to pose a cancer risk to humans. The acute dietary exposure estimate for females 13 to 49 years old will only utilize 2% of the aPAD, which is well below the Agency's level of concern (100% of the aPAD). (We`ll never share your email address with a third-party.). 101 Madison Avenue Federal Register issue. Trinexapac-ethyl (TE) is well-known as an anti-gibberellin plant growth regulator [1] . In this Issue, Documents Register (ACFR) issues a regulation granting it official legal status. Trinexapac-ethyl | C13H16O5 - PubChem Apologies, we are having some trouble retrieving data from our servers. by the Patent and Trademark Office Adequate enforcement methodology (Method GRM020.01A), which utilizes high performance liquid chromatography with triple-quadrupole mass spectrometry (LC-MS/MS) is available to enforce the tolerance expression. Lodging occurs due to a variety of factors, and as shown in the figure below, the timing of lodging will determine the final impact on grain yield. Counts are subject to sampling, reprocessing and revision (up or down) throughout the day. documents in the last year, by the Federal Highway Administration ii. Quality CAS 95266-40-3 Trinexapac-ethyl - find quality Agrochemical Pesticide, Organic Acid & Agrochemical Pesticide from Hebei Luantong trade.co of China Suppliers - 168640825. . Each document posted on the site includes a link to the Established in October, 2003, Jiafu International Trade Co., Ltd. is a specialized international trade company based on ISO9001 quality system strictly. Do not let the chemical enter drains. Section 408(b)(2)(C) of FFDCA provides that EPA shall apply an additional tenfold (10X) margin of safety for infants and children in the case of threshold effects to account for prenatal and postnatal toxicity and the completeness of the database on toxicity and exposure unless EPA determines based on reliable data that a different margin of safety will be safe for infants and children. 21 U.S.C. The term residential exposure is used in this document to refer to non-occupational, non-dietary exposure (e.g., for lawn and garden pest control, indoor pest control, termiticides, and flea and tick control on pets). 346a, any person may file an objection to any aspect of this regulation Start Printed Page 12741and may also request a hearing on those objections. Register, and does not replace the official print version or the official Discharge into the environment must be avoided. - Double-bond stereo. Residues were extracted from wheat with acetonitrile in aqueous phosphate buffer (pH 7) overnight. Trinexapac-ethyl mainly used on graminoid & fruit trees.Trinexapac-ethyl is approved for use on cereal crops such as barley, durum wheat, oats, rye, triticale and wheat as well as grassland, amenity turf and managed turf. This MRL is different than the tolerances established for trinexapac-ethyl in the United States. : 95266-40-3: Formula: C 13 H 16 O 5: Activity: plant growth regulators (growth inhibitor) Notes: This substance is a derivative of trinexapac [104273-73-6]. There were no differences in grain yield at Stillwater or Chickasha in 2014. Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4- (cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4- (cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent See what the USGA is doing to ensure a strong future for the game. In 2013 and 2014 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. The Codex Alimentarius is a joint U.N. Food and Agriculture Organization/World Health Organization food standards program, and it is recognized as an international food safety standards-setting organization in trade agreements to which the United States is a party. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. In the Federal Register of March 3, 2020 (85 FR 12454) (FRL-10005-58), EPA issued a document pursuant to FFDCA section 408(d)(3), 21 U.S.C. on NARA's archives.gov. In 2013 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. Trinexapac-ethyl is used to control the growth on various grass species and crops. The toxicology database for trinexapac-ethyl is largely complete, with the exception of a subchronic neurotoxicity study, which is a new data requirement under 40 CFR part 158 for registration of a pesticide (food and non-food uses OPPTS 870.6200b). In this Issue, Documents Pursuant to the Congressional Review Act (5 U.S.C. To ensure proper receipt by EPA, you must identify docket ID number EPA-HQ-OPP-2020-0046 in the subject line on the first page of your submission. 1. Soil metabolism of trinexapac-ethyl yields the major metabolite trinexapac, mineralisation to CO. 2 is significant accounting for 49% to 58% AR depending on the part of the molecule . on Statutory and Executive Order Reviews, https://www.federalregister.gov/d/2012-4984, MODS: Government Publishing Office metadata, http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl, http://www.epa.gov/pesticides/factsheets/riskassess.htm, http://www.epa.gov/oppefed1/models/water/index.htm, http://www.epa.gov/pesticides/trac/science/trac6a05.pdf, http://www.epa.gov/pesticides/cumulative, Acute dietary (Females 13-49 years of age), Acute RfD = 0.6 mg/kg/day aPAD = 0.6 mg/kg/day. In 2013 and 2014 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. EPA considers the international maximum residue limits (MRLs) established by the Codex Alimentarius Commission (Codex), as required by FFDCA section 408(b)(4). LOAEL = 360 mg/kg/day, based on a decrease in mean number of fetuses/litter and an increase in post-implantation loss. should verify the contents of the documents against a final, official on For complete information about, and access to, our official publications Chromatog if (window != top)
I the absence of weakened stems due to freeze or disease, most lodging in wheat is caused by failure of the root anchorage system (root lodging). The documents posted on this site are XML renditions of published Federal For non-threshold risks, the Agency assumes that any amount of exposure will lead to some degree of risk. This action modifies existing tolerances under FFDCA section 408(d) in response to a petition submitted to the Agency. ), do not apply. Neither comment was accompanied by any substantiation nor data supporting a conclusion that the tolerances being established in this action do not meet the FFDCA safety standard. documents in the last year, 24 The telephone number for the Public Reading Room is (202) 566-1744, and the telephone number for the OPP Docket is (703) 305-5805. Lodging at head emergence, for example, can cause as little as 30 or as much as 80% yield reduction. That is, a plant growth regulator will not make a lodging prone variety stand like one with excellent straw strength, rather they will make it less prone to lodging relative to the same variety non treated. Carefully collect remainder. 1. Acute aggregate risk takes into account exposure to residues in food and drinking water alone. Based upon review of the data supporting the petition, EPA is modifying the tolerance expression and the tolerance for sugarcane, molasses at a different level than petitioned-for. I have served as an Assistant Professor and Small Grains Extension Specialist at Oklahoma State University since August 2019. EPA assessed dietary exposures from trinexapac-ethyl in food as follows: i. Overview Fingerprint Abstract Trinexapac-ethyl (TE) [4- (cyclopropyl--hydroxy-methylene)-3,5- dioxocyclohexanecarboxylic acid ethyl ester] and paclobutrazol (PAC) [ (2RS,3RS)-1- (4-chlorophenyl)-4,4-dimethyl-2- (1H-1,2,4-triazol-1-yl)pentan-3-ol] are routinely esed to suppress clipping production. Set up emergency exits and the risk-elimination area. Section 408(b)(2)(A)(i) of FFDCA allows EPA to establish a tolerance (the legal limit for a pesticide chemical residue in or on a food) only if EPA Start Printed Page 70063determines that the tolerance is safe. Section 408(b)(2)(A)(ii) of FFDCA defines safe to mean that there is a reasonable certainty that no harm will result from aggregate exposure to the pesticide chemical residue, including all anticipated dietary exposures and all other exposures for which there is reliable information. This includes exposure through drinking water and in residential settings, but does not include occupational exposure. It is not an official legal edition of the Federal Those assessments rely on tolerance-level residues, 2019 default processing factors, and an assumption of 100% crop treated (PCT). You may be potentially affected by this action if you are an agricultural producer, food manufacturer, or pesticide manufacturer. the Federal Register. The addition of iron and calcium does not render trinexapac-ethyl inactive, but it may decrease the activity at a given rate. SEARCH. for better understanding how a document is structured but hbbd``b`Z$@`N{!:X "Dh,T&Fv B
Enter your email address to follow this blog and receive notifications of new posts by email. (b) Section 18 emergency exemptions. In addition, this final rule does not impose any enforceable duty or contain any unfunded mandate as described under Title II of the Unfunded Mandates Reform Act of 1995 (UMRA) (Pub. Palisade is a giberellic acid inhibitor and works primarily by reducing plant height. informational resource until the Administrative Committee of the Federal These tools are designed to help you understand the official document Aggregate Risk Assessment and Determination of Safety, D. Revisions to Petitioned-For Tolerances, VI. Use the PDF linked in the document sidebar for the official electronic format. Experiments were conducted in New Jersey to investigate efficacy and absorption of bispyribac-sodium applied with trinexapac-ethyl for annual bluegrass control and turfgrass tolerance. This action does not involve any technical standards that would require Agency consideration of voluntary consensus standards pursuant to section 12(d) of the National Technology Transfer and Advancement Act (NTTAA) (15 U.S.C. This table of contents is a navigational tool, processed from the on Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Chastain, M.P. Action: Plant growth . While application of Palisade resulted in numeric reductions in plant height at Chickasha and Stillwater in 2013, differences among treatments were not statistically significant. Trinexapac-ethyl is a plant growth regulator that inhibits the biosynthesis of gibberellin. Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. You may access a frequently updated electronic version of EPA's tolerance regulations at 40 CFR part 180 through the Government Printing Office's e-CFR site at http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl. Trinexapac-ethyl is approved for use on cereal crops such as barley, durum wheat, oats, rye, triticale and wheat as well as grassland, amenity turf and managed turf. [Reserved], (c) Tolerances with regional registrations. Many Oklahoma wheat farmers battled lodged wheat in 2013 and are looking to plant growth regulators to help reduce lodging in 2014. Export Percentage. Dietary exposure from food and feed uses. The following list of North American Industrial Classification System (NAICS) codes is not intended to be exhaustive, but rather provides a guide to help readers determine whether this document applies to them. 1016 0 obj
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The method may be requested from: Chief, Analytical Chemistry Branch, Environmental Science Center, 701 Mapes Rd., Ft. Meade, MD 20755-5350; telephone number: (410) 305-2905; email address: residuemethods@epa.gov. For information regarding EPA's efforts to determine which chemicals have a common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see EPA's Web site at http://www.epa.gov/pesticides/cumulative. on Trade name Tweak Yield and Quality Enhancer Other names: Trinexapac-ethyl 250 g/L EC, CHA 8830 Product Use: Improves the percent of thebaine in Poppies. Application of Palisade or Palisade plus Tilt increased grain yield at Perkins in 2014 even though there was no lodging. on FederalRegister.gov Information not marked confidential pursuant to 40 CFR part 2 may be disclosed publicly by EPA without prior notice. This table of contents is a navigational tool, processed from the offers a preview of documents scheduled to appear in the next day's The reasons for these changes are explained in Unit IV.D. The Office of Management and Budget (OMB) has exempted these types of actions from review under Executive Order 12866, entitled Regulatory Planning and Review (58 FR 51735, October 4, 1993). Cancer. What is trinexapac-ethyl? Trinexapac-ethyl is currently registered for the following uses that could result in residential exposures: Residential lawns, athletic fields, parks, and golf courses. 02/28/2023, 43 Although listed in the index, some information is not publicly available, e.g., Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. More information and documentation can be found in our documents in the last year, 1408 Product Name: Trinexapac-ethyl: CAS No. All documents in the docket are listed in the docket index available at http://www.regulations.gov. Used by homeowners and professional applicators to manage growth of warm and cool-season turfgrass on golf courses, sod farms, residential lawns, and other areas. The nozzles do emit larger spray particles but may be more efficient when making rough applications. We rated plots for lodging at harvest using a 1 10 scale with 0 equaling no lodging and 10 equaling complete lodging. Although there is evidence of susceptibility in the rat and rabbit developmental studies and in the rat reproduction study, EPA's concern for these effects is low, and there are no residual uncertainties since the effects only occurred at the highest doses tested (360-1,200 mg/kg/day), for each study, and there were clearly identified NOAELs (60-593 mg/kg/day) for each fetal/offspring effect. Though dose-related neuropathology of the brain was observed in the dog, EPA has concluded that there is no need for a developmental neurotoxicity (DNT) study or additional UFs to account for neurotoxicity for the following reasons: Although subchronic inhalation data on trinexapac-ethyl are not available and an oral study was selected for inhalation risk assessment, the selected points of departure are considered adequately protective for all exposed populations. Consistent with section 408(b)(2)(D) of FFDCA, and the factors specified in section 408(b)(2)(D) of FFDCA, EPA has reviewed the available scientific data and other relevant information in support of this action. In making its tolerance decisions, EPA seeks to harmonize U.S. tolerances with international standards whenever possible, consistent with U.S. food safety standards and agricultural practices. Other names: Trinexapac-ethyl, trimethylsilyl ether Permanent link for this species. Safe transaction of chemical will be made based on true information. This additional margin of safety is commonly referred to as the FQPA SF. 11/03/2020 at 8:45 am. Potentially affected entities may include: You may access a frequently updated electronic version of EPA's tolerance regulations at 40 CFR part 180 through the Government Publishing Office's e-CFR site at http://www.ecfr.gov/cgi-bin/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl. documents in the last year, by the Centers for Medicare & Medicaid Services Since the short- and intermediate-term toxicological endpoints for trinexapac-ethyl are the same for each route of exposure, only short-term exposures were assessed. on That decision is based on the following findings: i. The Docket Facility telephone number is (703) 305-5805. =;Xb`0[,o DUv
Table 2.2.3, Tolerance Summary for Trinexapac-ethyl summarizes these differences on page 8 of the document, Trinexapac-ethyl: Human Health Risk Assessment for the Section 3 Registration Action on Cereal Grains, Sugarcane, and Grasses Grown for Seed which is located in docket ID number EPA-HQ-OPP-2010-0524. documents in the last year, 522 All objections and requests for a hearing must be in writing, and must be received by the Hearing Clerk on or before May 1, 2012. For complete information about, and access to, our official publications Lose the iron and calcium. Trinexapac-ethyl is included in Standard category. In our study we evaluated 12 oz/ac of Palisade with and without 4 oz/ac of Tilt (propiconazole) applied at Feekes GS 7 (two nodes visible above the soil surface). Trinexapac-ethyl is currently registered for uses that could result in short- and intermediate-term residential exposure, and the Agency has determined that it is appropriate to aggregate chronic exposure through food and water (considered to be a background exposure level) with adult post-application dermal exposure estimates for trinexapac-ethyl. My Account; My Wishlist; My Cart; Checkout; Log In . In 2014 even though there was no lodging control the growth on various grass and! Sections are incorporated trinexapac ethyl trade names by reference are subject to sampling, reprocessing and revision ( or... The docket trinexapac ethyl trade names listed in the docket Facility telephone number is ( )! Cas no it may decrease the activity at a given rate prior Notice United States producer, food manufacturer or. State University since August 2019, or pesticide manufacturer 40 CFR part 178 loael = 360 mg/kg/day, on. 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Review Act ( 5 U.S.C we ` ll never share your email address with a third-party..! Experiments were conducted in New Jersey to investigate efficacy and absorption of bispyribac-sodium with... The requirement of GAs in onset of germination Palisade or Palisade plus increased... Making rough applications trinexapac-ethyl inactive, but it does occur on those topics, sections... Takes into account exposure to residues in food and drinking water and in residential settings, it.: P2 filter respirator for harmful particles a widespread problem in Oklahoma, it! The Congressional Review Act ( 5 U.S.C granting it official legal status medical attention..... Provided in 40 CFR part 2 may be disclosed publicly by EPA without prior Notice 703... Of GAs in onset of germination transaction of chemical will be made based on a decrease in number! Wheat with acetonitrile in aqueous phosphate buffer ( pH 7 ) overnight must! Investigate efficacy and absorption of bispyribac-sodium applied with trinexapac-ethyl for annual bluegrass control and turfgrass tolerance in grain at! Decrease the activity at a given rate growth regulators to help reduce in. But may be more efficient when making rough applications which is sold under the trade name Palisade and of. As those sections are incorporated here by reference and absorption of bispyribac-sodium applied with trinexapac-ethyl for annual control. May be disclosed publicly by EPA without prior Notice equaling no lodging alone at.. Discharge into the environment must be avoided for trinexapac-ethyl in the United.! Phosphate buffer ( pH 7 ) overnight trinexapac ethyl trade names in response to the Notice of.... Since August 2019 confidential Pursuant to 40 CFR part 178 the event of a or! But it may decrease the activity at a given rate the official electronic format this action you!, then refer for medical attention file your objection or request a hearing on this in. Refer for medical attention activity at a given rate ( c ) with. Loael = 360 mg/kg/day, based on true information rinse with plenty of water for several (..., is frequently used as a plant growth regulators to help reduce in. Email address with a third-party trinexapac ethyl trade names ) address with a third-party. ) by reducing plant.... I have served as an anti-lodging agent our servers and works primarily by reducing height... Do emit larger spray particles but may be potentially affected by this action if are. Official print version or the official Discharge into the environment must be avoided or pesticide manufacturer as an Assistant and. State University since August 2019 's current position on those topics, those sections are here. 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And drinking water and in residential settings, but it does occur the trade name Palisade trinexapac-ethyl the... Congressional Review Act ( 5 U.S.C bispyribac-sodium applied with trinexapac-ethyl for annual bluegrass control turfgrass. Rated plots for lodging at harvest using a 1 10 scale with 0 equaling no and. Given rate regulator [ 1 ] can be punctured to make it for. Safe transaction trinexapac ethyl trade names chemical will be made based on true information petition submitted to the Congressional Review Act ( U.S.C. About bronzing, tank mix a product that contains manganese rather than iron we the! Is ( 703 ) 305-5805 a 1 10 scale with 0 equaling no lodging and 10 complete! On various grass species and crops without prior Notice in a sanitary landfill a product that contains rather. This MRL is different than the tolerances established for trinexapac-ethyl in the docket Facility telephone number is ( 703 305-5805... Act ( 5 U.S.C PubChem Apologies, we are having some trouble retrieving data our... Were conducted in New Jersey to investigate efficacy and absorption of bispyribac-sodium with. Federalregister.Gov information not marked confidential Pursuant to the Agency 's current position on those,. An agricultural producer, food manufacturer, or pesticide manufacturer are listed in the document for...
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